| Pair Name | alpha-Mangostin, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | alpha-Mangostin (PubChem CID: 5281650 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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MOL
3D
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| Structure of Anticancer Drug |
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| Pair Name | alpha-Mangostin, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2B66.0] | Oral squamous cell carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in the S/G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | MYC | hsa4609 |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP7 | hsa840 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| In Vitro Model | HSC-4 | Tongue squamous cell carcinoma | Homo sapiens (Human) | CVCL_1289 |
| SAS | Tongue squamous cell carcinoma | Homo sapiens (Human) | CVCL_1675 | |
| Result | Synergism between α-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergism between α-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway. Oncol Rep. 2017 Dec;38(6):3439-3446. doi: 10.3892/or.2017.6030. | Click |
